It is a huge first task for the Blues head coach, who saw his side lose to Man City during a difficult pre-season.
All eyes will be on Stamford Bridge, both to watch how Maresca takes to life as Chelsea boss and to see if Pep Guardiola’s side can match the standards they have set in recent years.
Here’s everything you need to know about where to watch the game.
Where to watch Chelsea vs Man City
TV channel: In the UK, the game will be televised live on Sky Sports Main Event and Sky Sports Premier League, with coverage beginning at 4pm BST – after the conclusion of the London derby between Brentford and Crystal Palace. Kick-off is at 4.30pm.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.